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Pharmaceuticals and Biotechnology
Select a step where Air Liquide intervenes in your value chain.



Particle size reduction

Particle size reduction of APIs and excipients plays an important role in finished drug product performance and quality, with an impact on dissolution, bioavailability, content uniformity, and stability.

Cryogenic grinding, or cryo-grinding, involves cooling a material to low or very low temperatures with a cryogenic fluid (typically liquid nitrogen) in order to produce particles with a narrow size distribution. Cryogenic technology makes it possible to process soft or heat-sensitive products more efficiently and without the risk of thermal degradation.
As materials become brittle, fine powders can be obtained easily and with a minimum expenditure of energy. Micronization, using gaseous nitrogen to create high particle velocity and high-energy impact between particles, can also be used to reduce and control particle size and improve product homogeneity.

The resulting inert atmosphere further protects your products from oxidation, potential clumping due to atmospheric moisture, and reduces dust explosion risks.

Specialty Gases

Equipment for Specialty gases

  • Accessories
  • Cylinder storage & accessories
  • Flow devices
  • Gas delivery systems
  • Gas detection
  • Process Panels & Panels controllers
  • Purifiers & Filters
  • Regulators


Gas supply mode